Systemic fungal infections and patients with known hypersensitivity to the Methylprednisolone and its constituents.
Premature infant, because Methylprednisolone contain benzyl alcohol that has been reported to be associated with fatal “Gasping Syndrome”.
Long-term treatment is contra-indicated in duodenal and peptic ulcer, severe osteoporosis, patients with a history of psychosis, herpes.
Recent immunization.